Thrombosis and pulmonary embolism in corona
Shortly after the onset of the corona pandemic, scientists reported an increased rate of leg venous thrombosis and pulmonary embolism in patients with COVID-19. A new study confirms this high risk.
Patients with COVID-19 are at high risk for venous leg thrombosis and pulmonary embolism, according to a new study. (Image: Christoph Burgstedt / stock.adobe.com)
At the start of the pandemic, the SARS-CoV-2 coronavirus was often referred to as the respiratory virus. In the meantime, however, scientific studies have shown that the new pathogen is a “multi-organ virus” that affects many organs and often leads to thrombosis and pulmonary embolism. This is also confirmed by a new study.
Precise data on the risk of thrombosis determined
According to a current communication from the University of Medicine (MedUni) Vienna, researchers at the University Clinic for Internal Medicine I, Clinical Department of Hematology and Hemostaseology, have now been able to provide a systematic review of all data published globally on the topic “Thrombosis and pulmonary embolism in COVID-19 patients” for the first time to obtain precise data on the risk of thrombosis in hospitalized COVID-19 patients.
While patients who need to be hospitalized but not in an intensive care unit have a five to eleven percent risk, between 18 and 28 percent of those with severe COVID-19 suffer from leg vein thrombosis or embolism. pulmonary.
The results of the study were recently published in the journal “Research and Practice in Thrombosis and Haemostasis” (RPTH).
Anticoagulant administration recommended
“Even at the onset of the COVID-19 pandemic, some studies have reported an increase in the rate of pulmonary thrombosis and embolism. On this basis, but without corresponding evidence from controlled intervention studies, international therapeutic concepts have been developed and the forced administration of anticoagulant drugs has been recommended ”, explains Cihan Ay, head of the study.
“Our study is now being used to better understand this risk and should aid in making individual treatment decisions in individual patient groups using accurate risk assessment.”
For this review, researchers analyzed and assessed a total of 5,951 studies, of which 86 reported rates of thrombosis and pulmonary embolism in COVID-19 patients. Of these, 66 studies (28 173 patients) could be used for a meta-analysis to calculate a robust risk assessment for thrombosis.
Influence on the blood coagulation system
The researchers found that the overall prevalence of venous thromboembolism (VTE) was 14%, although many studies used thrombosis prophylaxis.
However, there was some heterogeneity in the subgroups. While the rate of VTE was highest among COVID-19 patients in intensive care, at 23%, the rate of VTE among those on the normal ward was 8%, a higher risk than that of patients otherwise hospitalized. . and patients with other internal diseases.
Another specific objective of the meta-analysis was to assess the risk of potentially fatal pulmonary embolism.
The result: “This risk is significantly higher than with other serious illnesses and is between 10 and 18% for patients requiring intensive care. Surprisingly, thrombosis could also be detected in almost half of COVID-19 hospital patients who were routinely screened for thrombosis by ultrasound. “
This recently highlights the influence of COVID-19 on the blood coagulation system. It could also be shown that patients who developed thrombosis or pulmonary embolism during the disease have a significantly increased D-dimer on admission to hospital, a laboratory value which indicates an activated coagulation system.
According to scientists, these results now provide a basis for assessing the risk of thrombosis based on the severity of the COVID-19 disease. Future studies must show whether an increase in D-dimer at hospitalization justifies an intensification of blood thinning. (a d)
Author and source information
This text conforms to the requirements of specialized medical literature, medical directives and current studies and has been verified by health professionals.
Medical University of Vienna: High risk of leg vein thrombosis and pulmonary embolism in patients with COVID-19, (accessed October 5, 2020), Medical University of Vienna Stephan Nopp, Florian Moik, Bernd Jilma, Ingrid Pabinger, Cihan Ay: Risk of vein thromboembolism in patients with COVID -19: A systematic review and meta-analysis; in: Research and Practice in Thrombosis and Haemostasis, (published: 25.09.2020), Research and Practice in Thrombosis and Haemostasis
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.