Heart Failure in Women – Women’s Hearts at Risk! – Portal of naturopathic and naturopathic specialists

When it comes to heart disease, many people think of it as a typical “male disease”. But women die much more often than men from heart failure, as the German Heart Foundation reports. Because heart failure is an often overlooked problem.

Symptoms of heart failure often don’t take heart failure seriously

Heart failure in women – an often overlooked problem. Women make up about half of all those affected in Germany. About a third of more women than men die from it. According to the German Heart Report, 25,318 women died of heart failure (heart failure) in 2016, compared to 15,016 men.

One of the reasons is probably that women don’t take the symptoms seriously. They experience shortness of breath when going up the stairs, have big legs or even a swollen stomach, are tired, feel weak and dizzy. It doesn’t occur to many of them that a weak heart could be behind. “Heart failure is very common in women, especially if the risk factors for high blood pressure, obesity and diabetes are present at the same time”, explains Professor Dr. med. Vera Regitz-Zagrosek.

The internist and cardiologist is a member of the scientific council of the German Heart Foundation and advises women to pay attention to certain points when seeing a doctor in order to protect themselves from easily preventable complications of their disease: if women are short of breath and are quickly exhausted, they should take theirs Ask a doctor to do a cardiac ultrasound (see box). The German Heart Foundation provides information on heart failure in women and many other aspects of heart failure as part of the National Heart Weeks at www.herzstiftung.de

Heart failure is a serious illness. The heart can no longer pump enough blood to the body. The heart pumps oxygen-rich blood through the left half of the heart into the blood vessels, through which it reaches the organs. After passing through the body, the now oxygen-poor blood returns to the heart. It passes through the right half of the heart into the lungs, is again enriched with oxygen and reaches the left half of the heart. The cycle begins again.

If the heart is weak, oxygen can no longer be transported to the lungs

If the heart is too weak, it cannot pump enough blood and therefore oxygen to the lungs or body (systole) or it cannot absorb enough blood (diastole). The latter is much more common in women than in men, as we know today. Women’s hearts are more rigid and therefore can expand less and fill with blood. Experts speak of a so-called diastolic heart failure with continued pumping function.

Experts fear many cases of heart failure going undetected in women

As women age, their hearts become even firmer. Because during menopause the lack of estrogen leads to increased blood pressure and increased connective tissue formation in the heart. “This heart failure caused by a lack of estrogen specific to the body cannot be compensated for by hormone therapy,” said Regitz-Zagrosek, also a Charité principal professor, Universitätsmedizin Berlin. Women not only have a firmer heart, but also smaller than men.

The smaller size is compensated by the fact that their hearts operate with a higher ejection fraction – as it is called in technical jargon – than that of men. The ejection fraction indicates the percentage of blood in the heart that is pumped through the body with each beat. In healthy men this is at least 55% of the blood in the heart, in healthy women more than 60%.

“So far, however, women have been guided by the minimum value for men of 55%,” explains the Berlin cardiologist. “Experts are currently discussing whether the minimum value for women is probably higher than that for men.” In addition: The ejection fraction normally increases with age, more in women than in men, as the size and mass of the heart decreases in both sexes. “This could once again contribute to the fact that the ejection fraction is considered normal, especially in many elderly women, even if they have suffered from a weak heart for a long time,” explains the expert. About half of all heart failure patients admitted to clinics now have a presumed normal ejection fraction. The majority of them are women.

Risk of pregnancy cardiomyopathy and broken heart syndrome

There are other special forms of heart failure in women. So-called perinatal cardiomyopathy (PPCM) can occur in the last third of pregnancy and about six months after birth. Warning signs are sudden shortness of breath, weakness, or water retention in the body. A doctor should be consulted immediately at the first signals.

Experts fear many cases of heart failure going undetected in women. (Image: Robert Kneschke / fotolia.com)

Broken heart syndrome is heart failure that occurs almost exclusively in postmenopausal women. It is often the result of massive emotional stress. The symptoms are similar to those of a heart attack: shortness of breath, chest tightness, severe pain. “The heart contracts more strongly at the base than at the top,” explains Regitz-Zagrosek. “Due to this imbalance in the contraction process, too little blood is ejected and the body is not sufficiently supplied.” This condition is also life threatening. Those affected must immediately alert the emergency doctor (emergency number 112).

Take care of your heart – Professor Vera Regitz-Zagrosek advises women:
– If you have difficulty breathing during minor exertion and quickly become exhausted, ask your doctor for a cardiac ultrasound.

– Have your blood pressure, blood sugar, body weight and blood lipids checked regularly.

– Ask your doctor for a blood test. Iron deficiency can be a sign of a weak heart. In addition, two important markers, the natriuretic peptides ANP and BNP, are elevated in heart failure. Important: in women, slightly elevated values ​​are warning signs.

– Women need lower doses of ACEs and beta blockers than men. Digitalis can cause more complications. The administration of drugs for cardiac arrhythmias should be closely monitored using an electrocardiogram. Ask your doctor if the recommended medicine has been tried on women and if special dosages are recommended.

– In case of possible side effects of a medicine, do not change the dose on your own or stop using it, but talk to your doctor.

– Women benefit greatly from resynchronization therapy, in which the heart is made to contract synchronously with special pacemakers. Do not decline such an offer in advance.
– Exercise outdoors, eat healthy, avoid alcohol and cigarettes.

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

How to recognize a Covid-19 disease – Naturopathic and naturopathic specialists portal

At first glance, the so-called corona symptoms do not differ from the symptoms of the flu. But there are some very specific distinguishing features. (Image: zigres / stock.adobe.com)

The Robert Koch Institute (RKI) today reported 6,638 new infections and 34 new deaths in 24 hours. The second wave of infections has therefore reached Germany. The difference between a coronavirus infection and a seasonal flu is hard to see at first glance for laymen but also for medical personnel. However, there are specific unique selling points that point to a coronavirus infection.

In addition to the available test methods, the present symptoms also indicate which disease may be the cause of the symptoms. Because in addition to a few similarities, there are also differences.

Virus transmission

Influenza viruses and coronaviruses are spread from person to person in the same way, that is, mainly through droplets that escape from the nose and mouth – especially when someone a cough, sneeze or talk. If another person inhales such droplets in the air, there is a risk of infection. Infection is also possible by touching contaminated surfaces and then touching the mouth, nose or eyes. Since COVID-19 is a new disease, there are hardly any immunities in the population, which is why SARS-CoV-2 is much more contagious than influenza viruses.

Common symptoms of COVID-19 and flu are common, says infectious disease specialist

Differences from COVID-19

Some people with COVID-19 also develop other symptoms. “Patients with COVID-19 have more diarrhea or nausea and vomiting,” reports Dr. Kristin Englund, infectious disease specialist at the Cleveland Clinic in the United States. Changes in smell or taste and confusion are also not uncommon with COVID-19. “COVID-19 appears to affect more organs in the body than the flu,” the researcher said.

COVID-19 lasts longer than the flu

As Dr. Englund reports that there are also differences in the duration of the disease. “Typically, flu symptoms persist for four or five days, or even seven days,” says the doctor. However, a COVID-19 illness lasts an average of ten days, and even longer if the course is severe.

Complications of influenza and COVID-19

Complications can occur with both diseases. The flu along with COVID-19 can lead to pneumonia, acute respiratory distress syndrome, and inflammation of the heart, brain, or muscle tissue. The risk of complications is higher in older people and in people with underlying illnesses. Dr. According to Englund, there are additional complications with COVID-19. For example, blood clots and multisystem inflammation can occur.

Massive events

“What we’re seeing with COVID-19 are the so-called ‘mass media events’, where an infected person goes to a meeting or party, but doesn’t necessarily have symptoms – and still transmits the virus to many people in his area, “reports Dr. Englund.

Contact a doctor in case of suspicion

However, only a test can provide a reliable distinction. The infectious disease specialist strongly recommends contacting a doctor if you suspect an infection. It doesn’t matter if it’s the flu or COVID-19. (sb, vb)

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Sources:

Cleveland Clinic: Influenza vs. COVID-19: Can you tell the difference? (published: 09/10/2020), clevelandclinic.org

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

In case of heart problems or heart stumbles, make an appointment quickly with your doctor – Portal of specialists in naturopathy and naturopathy

Appointments with a specialist should not be canceled for fear of a coronavirus infection. (Image: motortion / Stock.Adobe.com)

Due to the growing number of corona infections, many patients are canceling important appointments with their specialist. In the case of heart disease, in particular, therapy is very important to avoid deterioration of health. The German Senior League (DSL) eV underlines this in a press release.

Fear of infection: many people cancel appointments with a specialist

In recent months, many people have canceled their appointments with a specialist for fear of becoming infected with the coronavirus. Reliable treatment, however, is particularly important for heart disease, in order to avoid deterioration of health and dangerous secondary diseases. If, for example, arrhythmia, atrial fibrillation is not recognized and treated appropriately, it greatly increases the risk of stroke. The German Senior League has summarized the most important facts in a brochure and website.

Why palpitations endanger the brain

In atrial fibrillation, the regulated process of tension and relaxation of the muscles of the atria is disturbed. This can mean that the blood in the heart chambers is not being pumped properly. The cells of the body can receive less oxygen; Physical weakness, shortness of breath and dizziness can result.

A blood clot can be at risk

In the worst case, the blood stays in the atria for too long and clumps together. If such a blood clot enters a vessel supplying the brain, it can clog it, interrupt the blood supply and thus trigger a stroke. To prevent this from happening, high risk patients need stroke prophylactic drugs. There is a high risk when various factors combine, for example heart failure, age over 65, high blood pressure or diabetes.

Atrial fibrillation – reducing the risk of stroke

The updated booklet “Atrial Fibrillation – Reducing the Risk of Stroke” explains the relationships described and shows the treatment options and possibilities for a preventive lifestyle. The brochure can be requested free of charge in print or downloaded as a PDF from the website. It was produced with the support of Pfizer Pharma GmbH. Ordering address: German Senior League (DSL) eV, Heilsbachstraße 32, 53123 Bonn. (sb, pm)

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Sources:

PM: Stroke Prevention: If you have heart problems, keep your doctor’s appointments as regularly as possible (accessed October 14, 2020), dsl-vorhofflimmern.de

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

What are the neuropsychiatric consequences? – Portal of naturopathic and naturopathic specialists

Psychological and Neurological Effects of COVID-19

So far, medicine has mainly focused on the acute physical effects and their mitigation in the case of COVID-19, but psychological and neurological consequences are also to be feared, which can significantly affect those affected in the long term. term.

The possible acute and chronic neuropsychiatric consequences of COVID-19 are discussed in a current article in the famous specialist magazine “BMJ”. First of all, it is clear that there are still massive uncertainties in this area today. In addition, the first results of the study are named and indicate acute central nervous system (CNS) damage and long-term complaints such as chronic fatigue or cognitive impairment due to COVID-19.

Damage to the central nervous system

Basically, “viral respiratory tract infections can have multi-systemic effects, including on the central nervous system (CNS), and thus trigger a spectrum of psychiatric and neurological disorders”, point out the authors of the specialized article. In the case of COVID-19, it is now also known that various CNS abnormalities can occur with potentially serious and long-term consequences.

Consequences of COVID-19

Various studies have also shown evidence of brain inflammation, leukoencephalopathy and micro-bleeding in the brain in severe courses of COVID-19, writes Matthew Butler’s team from the Institute of Psychiatry, Psychology and Neuroscience. from King’s College London.

In addition, there are other biological mechanisms, including autoimmunity, which may be just as relevant to psychological sequelae as the psychological trauma of the life-threatening disease and the socio-economic stress associated with the pandemic. added the experts.

Delirium is a common symptom

According to the researchers, acute confusion (delirium) should be mentioned first as a possible neuropsychiatric symptom. It might also be the only hallmark of the disease in the elderly and people with dementia. Screening for delirium is therefore recommended, especially in the elderly or in people with pre-existing dementia. One-third of people with delirium reported cognitive and behavioral abnormalities even after discharge.

Other consequences of infection

Depression and anxiety are other possible complaints in the acute phase of the infection. In addition, the UK-based CoroNerve group has collected data on neurological and neuropsychiatric disorders from COVID-19, which shows psychoses, mood disorders and so-called catatonia as well as encephalopathies, encephalitis and other neurological disorders can occur, the researchers report.

Anxiety, depression, PTSD

The risk of anxiety, depression, and post-traumatic stress disorder (PTSD) is also relatively high among people hospitalized with COVID-19. Additionally, crippling fatigue and cognitive difficulties often occur after discharge, according to contributors. Even sick people who did not have to be treated in the hospital have reported a variety of symptoms that can occur months after an acute infection.

While it is too early to assess the full effect of long-term complications, looking to the future, it is assumed that the long-term consequences of COVID-19 “will lead to significant morbidity in the population with serious implications for the population. health and social welfare will lead, ”summarize the experts.

Further research that will inform clinical guidelines and advance our understanding of the mechanisms underlying COVID-19 is urgently needed, the researchers added. However, it can take years for a complete picture to emerge. (fp)

With COVID-19, there is also a threat of long-term neuropsychiatric consequences. (Image: Ahmet Aglamaz / Stock.Adobe.com)

Author and source information

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Author:

Dipl. Geogr. Fabian Peters

Sources:

Matthew Butler, Thomas A. Pollak, Alasdair G. Rooney, Benedict D. Michael, Timothy R. Nicholson: neuropsychiatric complications of covid-19; in: BMJ (published October 13, 2020), bmj.com

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

New combination therapy for better treatment – Naturopathic and naturopathic specialists portal

How can cancer be optimally treated?

Combination therapies appear to have great potential to destroy cancer cells. Now, a chemotherapeutic and photodynamic approach has been combined, which ultimately leads to the destruction of tumor cells.

A combination of active ingredients can effectively kill cancer cells, according to a joint study by researchers at the Max Planck Institute for Polymer Research and Dalian University of Technology in China. The study was published in the journal “Angewandte Chemie”.

How do cancer drugs work?

Different cancer drugs use different strategies. DNA-damaging agents cause, for example, that the DNA is disrupted and the tumor cannot grow. In contrast, photodynamic agents generate reactive oxygen species (ROS) when exposed to light. These ROSs (often also called oxygen radicals) then interfere with the organelles of the cell and drive the cells in the direction of programmed cell death, known as apoptosis, the researchers explain.

Cancer resistance to drugs

However, some cancers have already developed resistance. In such cases, the drug cannot enter the cell or the cells quickly repair damaged DNA strands.

Combined drug in nanocapsule

In order to increase the effectiveness of anticancer drugs, researchers at the Max Planck Institute for Polymer Research and researchers at Dalian University of Technology have combined chemotherapeutic and photodynamic agents. All the active ingredients were enclosed in a nanocapsule, from which they were delivered directly to tumor cells.

The nanocapsules have been encapsulated with a protein shell and the light irradiation then triggers a cascade of events that ultimately result in the destruction of tumor cells, the research group explains in a press release.

Structure of nanocapsules

According to the team, it was a particular challenge to assemble all the reagents in a nanocapsule. The chemotherapeutic agent cisplatin is said to be poorly soluble in water, while the nanocapsule protein ovalbumin does not dissolve in the organic solvent. Using a mini-emulsion technique, all of the reagents were finally combined in a mixture of solvents and enclosed in an ovalbumin shell.

Benefits of combined treatment

The drugs have been tested on tumor cell lines. Nanocapsules entered cells, released their charge, and developed ROS when exposed to red light. The active ingredients also killed cells that were normally resistant to cisplatin or that had particularly low oxygen concentration.

The drugs also worked in mice

The combined encapsulated drugs also arrested tumor growth in experiments with live mice. The team was able to show that the reagents accumulated in the tumor tissue. They also made tumors shrink over time without affecting healthy tissue or other organs.

The anticancer drugs contained in the nanocapsules were administered to the tumor and acted synergistically there. Treatments with a single active ingredient or a combination of two active ingredients were much less effective. Similar synergistic platforms for drug delivery will play an important role in future therapeutic settings, experts summarize. (as)

Will cancer be treated more effectively with the help of combination drugs in the future? (Image: Rido / Stock.Adobe.com)

Author and source information

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Sources:

Shuai Jiang, Ming Xiao, Wen Sun, Daniel Crespy, Volker Mailänder et al .: Synergistic Anticancer Therapy by Ovalbumin Encapsulation – Enabled Tandem Reactive Oxygen Species Generation, in Angewandte Chemie (published July 19, 2020), Angewandte Chemie (published October 13, 2020) 2020), Angewandte Chemie

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

Sleep Drastically Affects Attention – Naturopathic Treatment Portal

Sleeping Longer Has Mindfulness Benefits

Sleeping longer seems to be the key to improving alertness, which has many benefits for everyday well-being and performance at work. To improve alertness, 29 minutes of extra sleep per night is sufficient.

Sleeping 29 minutes more at night has a positive effect on alertness and therefore on well-being and performance at work the next day, according to a study conducted by researchers at the University of South Florida. The study was published in the English language journal “Sleep Health”.

Mindfulness is important for healthcare professionals

It is possible to be alert and alert, but not necessarily alert. You may also be tired or not paying attention, but be careful all the same, the researchers say. So-called conscious attention means more than just being awake. Because attention control and self-regulation can facilitate sensitivity and adaptive adaptation to environmental influences and internal stimuli, which are essential for the effective management of stressful situations.

Differences from previous studies

Unlike previous studies, current research has analyzed how the multiple dimensions of nighttime sleep affect daily attention or mindfulness rather than focusing only on sleep quality or sleep duration, the team explains.

Healthcare professionals were examined

Better sleep has been found to increase mindfulness the next day and reduce drowsiness that occurs during the day.

Sleep problems with healthcare professionals

Sleep problems are prevalent among medical staff due to shift work and psychological stress associated with treating life-threatening illnesses or deaths.

Effects of improved sleep

Current research is focused on nurses, a group of health care professionals who need a lot of attention. The 61 participants were followed medically for a period of two weeks. Several features of sleep health were examined, and participants were asked to answer questions about their level of consciousness and sleepiness three times a day for two weeks. For example, one possible answer to the questions was: I found it difficult to focus on what was going on.

Daily mindfulness was measured using a mindfulness scale and participants also wore an Actiwatch Spectrum device for two weeks during the study period, which measured wrist movement activity in order to quantify patterns of sleep and wakefulness.

Mindfulness reduces daytime sleepiness

The researchers concluded that participants’ attentive attention was higher than usual after nights with better quality of sleep and longer sleep duration (half an hour longer). Conscious attention was also associated with less drowsiness on the same day, and people with more conscious attention were 66% less likely to experience symptoms of insomnia during the two-week study period, the team reports. research.

The results of this study suggest that behavioral-focused health intervention strategies are needed for a wider range of people in the healthcare industry to improve sleep and mindfulness, the researchers summarize. Given the relationship between conscious attention and better care for people in hospitals, improving sleep for people in healthcare could also bring significant health benefits. (as)

Nighttime sleep affects mindfulness and therefore also the management of stress and drowsiness during the day. (Image: Prostock-studio / Stock.Adobe.com)

Author and source information

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Sources:

Soomi Lee, Christina Mu, Brian D. Gonzalez, Christine E. Vinci, Brent J. Small: Sleep Health Is Associated With Next Day Conscious Attention In Healthcare Workers, In Sleep Health (Posted October 1, 2020 ), Sleep Health University of South Florida: Sleep Health Drives Successful Mindfulness Practice (published October 13, 2020), University of South Florida

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

Fasting Helps You Lose Weight and Repair Human Cells – Naturopathic and Naturopathic Specialists Portal

If you fast and therefore consume fewer calories than you consume, you not only lose weight over time, but you are also actively doing something good for your cells and therefore your health. (Image: Julien Tromeur / stock.adobe.com)

Fasting promotes cell repair

When fasting, certain foods are totally or partially avoided for a period of time. These fasting remedies not only help you lose weight but also bring other health benefits beyond weight loss. Among other things, they promote the repair of human cells, the researchers report.

Many scientific studies have shown that fasting has a positive effect on health. A research team from the University of Albstadt-Sigmaringen has now demonstrated a link between calorie reduction and positive effects on cell repair processes in humans.

Fasters are doing something good for their health

People who fast and eat fewer calories than they use not only lose weight over time. On top of that, they are actively doing something good for their cells and therefore for their health: a research group at the University of Applied Sciences in Albstadt-Sigmaringen led by Prof. Dr. According to a press release, Jörg Bergemann has shown in several publications that fasting FX-Mayr therapy has a positive effect on the central functions of human cells.

Stimulation of the cell’s own repair processes

“Several 10,000 DNA damages occur in all of our cells every day,” explains Jörg Bergemann, dean of studies for the master’s program in biomedical sciences. “If these are not repaired, it can lead to serious functional loss and illness.” According to the expert, too little attention is still paid to the importance of stimulating cell repair processes to maintain our health.

“This aspect is extremely important.” For this reason, Bergemann and his team are also working intensively on the development of sensing systems to measure these processes directly on people. “This is not only an important focus of work in the course, but also at the Center for Health and Biomedical Sciences at Innocamp in Sigmaringen.”

Vital functions of mitochondria

According to reports, a publication by Katja Matt is the basis for work in this area. The scientist was able to prove that an FX Mayr fasting cure can stimulate the cell’s own repair. “In addition, stimulated processes have a positive effect on cell aging,” explains the researcher. “This underlines the high therapeutic benefit of these fasting remedies.” The results have since been confirmed by Alica Schöller-Mann. In addition, she was able to show that this form of fasting also stimulates the vital functions of the mitochondria, which act as “powerhouses” of cells and are key suppliers of energy.

And Barbara Hochecker described that these positive effects of a fasting cure can be supported by active ingredients such as spermidine. “Spermidine has a particularly positive effect on the self-cleaning of our cells, the so-called autophagy”, explains Jörg Bergemann. The team is therefore working hard on an autophagy detection system.

With their research, scientists at the University of Albstadt-Sigmaringen want to raise awareness of the relatively simple ways in which everyone can actively do something for their health. “If you factor in the number of positive effects a calorie reduction has on the cell’s own repair, mitochondrial functions, and the cell’s garbage disposal, this is an important additional incentive for a fast.” , explains Bergemann. (a d)

Author and source information

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

Effective combination therapy for cancer treatment – Naturopathic and naturopathic specialist portal

How can cancer be optimally treated?

Combination therapies appear to have great potential to destroy cancer cells. Now, a chemotherapeutic and photodynamic approach has been combined, which ultimately leads to the destruction of tumor cells.

A combination of active ingredients can effectively kill cancer cells, according to a joint study by researchers at the Max Planck Institute for Polymer Research and Dalian University of Technology in China. The study was published in the journal “Angewandte Chemie”.

How do cancer drugs work?

Different cancer drugs use different strategies. DNA-damaging agents cause, for example, that the DNA is disrupted and the tumor cannot grow. In contrast, photodynamic agents generate reactive oxygen species (ROS) when exposed to light. These ROSs (often also called oxygen radicals) then interfere with the organelles of the cell and drive the cells in the direction of programmed cell death, known as apoptosis, the researchers explain.

Cancer resistance to drugs

However, some cancers have already developed resistance. In such cases, the drug cannot enter the cell or the cells quickly repair damaged DNA strands.

Combined drug in nanocapsule

In order to increase the effectiveness of anticancer drugs, researchers at the Max Planck Institute for Polymer Research and researchers at Dalian University of Technology have combined chemotherapeutic and photodynamic agents. All the active ingredients were enclosed in a nanocapsule, from which they were delivered directly to tumor cells.

The nanocapsules have been encapsulated with a protein shell and the light irradiation then triggers a cascade of events that ultimately result in the destruction of tumor cells, the research group explains in a press release.

Structure of nanocapsules

According to the team, it was a particular challenge to assemble all the reagents in a nanocapsule. The chemotherapeutic agent cisplatin is said to be poorly soluble in water, while the nanocapsule protein ovalbumin does not dissolve in the organic solvent. Using a mini-emulsion technique, all of the reagents were finally combined in a mixture of solvents and enclosed in an ovalbumin shell.

Benefits of combined treatment

The drugs have been tested on tumor cell lines. Nanocapsules entered cells, released their charge, and developed ROS when exposed to red light. The active ingredients also killed cells that were normally resistant to cisplatin or that had particularly low oxygen concentration.

The drugs also worked in mice

The combined encapsulated drugs also arrested tumor growth in experiments with live mice. The team was able to show that the reagents accumulated in the tumor tissue. They also made tumors shrink over time without affecting healthy tissue or other organs.

The anticancer drugs contained in the nanocapsules were administered to the tumor and acted synergistically there. Treatments with a single active ingredient or a combination of two active ingredients were much less effective. Similar synergistic platforms for drug delivery will play an important role in future therapeutic settings, experts summarize. (as)

Will cancer be treated more effectively with the help of combination drugs in the future? (Image: Rido / Stock.Adobe.com)

Author and source information

Fade now

This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Sources:

Shuai Jiang, Ming Xiao, Wen Sun, Daniel Crespy, Volker Mailänder et al .: Synergistic Anticancer Therapy by Ovalbumin Encapsulation – Enabled Tandem Reactive Oxygen Species Generation, in Angewandte Chemie (published July 19, 2020), Angewandte Chemie (published October 13, 2020) 2020), Angewandte Chemie

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.

Product sold at affected Aldi – Naturopathic and naturopathic specialists portal

Frischebox GmbH recalls the product “NATUR Lieblinge – pieces of coconut”. Salmonella has been detected in the product sold at Aldi. Consumption is not recommended. (Image: gui yong nian / stock.adobe.com)

Health risk: recall at Aldi

Frischebox GmbH from Rheinstetten (Baden-Württemberg) has launched a recall for the product “NATUR Lieblinge – Pieces of coconut” in 100 gram packaging. Reason for measurement: Salmonella was detected in the product sold at Aldi. A risk to health cannot be excluded.

Frischebox GmbH from Rheinstetten in Baden-Württemberg calls the product “NATUR Lieblinge – Pieces of coconut, 100g” (Lot: L: 3501 1177 and L: 3405 1175, best before: May 24, 2021, origin: MZ (Mozambique) – information on the back of the product) rear.

Salmonella detected

According to consumer information published by the Federal Office for Consumer Protection and Food Safety (BVL) on its portal “food warning.de”, Salmonella was detected in the product as part of a self-inspection. .

According to the information, the product concerned was sold throughout Germany at all branches of Aldi Süd. The grocery discounter has already collected the merchandise. Customers can return the product to any Aldi Süd branch and have the purchase price refunded, even without showing the receipt. Frischebox GmbH points out that other products and products from other batches / expiration dates are not affected.

The risk to health cannot be excluded

“Salmonella can manifest itself in a few days with diarrhea, abdominal pain, vomiting and a slight fever. People with weakened immune systems, such as infants, toddlers or the elderly, are particularly at risk, ”the company writes. Since a health risk cannot be excluded, customers should be careful with the recall and not consume the affected product.

Experts say people who have eaten the affected foods and develop severe or persistent symptoms should see a doctor and advise them of a possible Salmonella infection. However, it doesn’t make sense to seek preventative medical treatment without symptoms. (Ad)

Author and source information

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This text complies with the requirements of specialized medical literature, medical directives and ongoing studies and has been verified by healthcare professionals.

Sources:

Federal Office for Consumer Protection and Food Safety: Details of food warnings, (accessed October 14, 2020), food warning.delebensmittelwarnung.de: consumer information of Frischebox GmbH, (accessed October 14, 2020), food warning. of

Important note:
This article is provided for informational purposes only and should not be used for self-diagnosis or self-treatment. It cannot replace a visit to the doctor.